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    83207-58-3

    • Product Name:Astragaloside A
    • Molecular Formula:C41H68O14
    • Molecular Weight:784.983
    • Appearance:white powder
    Inquiry

    Product Details

    pd_meltingpoint:284-286oC

    Appearance:white powder

    Purity:99%

    Trustworthy Factory Supply Astragaloside A, Factory Sells 83207-58-3 with Lowest Price

    • Molecular Formula:C41H68O14
    • Molecular Weight:784.983
    • Appearance/Colour:white powder 
    • Vapor Pressure:0mmHg at 25°C 
    • Melting Point:284-286oC 
    • Refractive Index:1.62 
    • Boiling Point:895.666 °C at 760 mmHg 
    • PKA:12.91±0.70(Predicted) 
    • Flash Point:495.481 °C 
    • PSA:228.22000 
    • Density:1.395 g/cm3 
    • LogP:0.72410 

    Astragaloside A(Cas 83207-58-3) Usage

    Description

    Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases.

    Uses

    Astragalosides are bioactive saponins isolated from dried roots of plants of the genus Astragalus, which is used in traditional Chinese medicine. Astragaloside A, also known as astragaloside IV, is known to have diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. More specifically, it protects cardiomyocytes from apoptosis resulting from ischemia/reperfusion and inhibits inflammation signaled through TNF-α. Furthermore, astragaloside A stimulates angiogenesis, promotes the differentiation of neural stem cells, and increases neuroregeneration.

    Health effects

    As the main active ingredient of the Chinese medicine Astragalus membranaceus, Astragaloside A has a good regulatory effect on the heart. It can protect against ischemic and hypoxic cardiomyocytes, protect the heart structure, and enhance heart function.

    Pharmaceutical Applications

    Astrageloside A has multiple pharmacologic effects, including anti-inflammatory, antifibrotic, antioxidative stress, anti-asthma, antidiabetes, immunoregulation, and cardioprotective effect via numerous signaling pathways. According to the existing studies and clinical practices, Astragaloside A possesses potential for broad application in many diseases.

    InChI:InChI=1/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24-,25-,26-,27?,28-,29+,30?,31-,32-,33-,34+,37+,38-,39+,40-,41+/m0/s1

    83207-58-3 Relevant articles

    TRITERPENE GLYCOSIDES OF Astragalus AND THEIR GENINS. XV. CYCLOSIVERSIOSIDES B AND D FROM Astragalus basineri

    Umarova, R. U.,Svechnikova, A. N.,Abdullaev, N. D.,Gorovich, M. B.,Abubakirov, N. K.

    , p. 174 - 177 (1984)

    Two new glycosides have been isolated fr...

    Functional Characterization and Protein Engineering of a Triterpene 3-/6-/2′-O-Glycosyltransferase Reveal a Conserved Residue Critical for the Regiospecificity

    Bao, Yang-Oujie,Gao, Bai-Han,Li, Fu-Dong,Qiao, Xue,Shi, Xiao-Meng,Su, Hui-Fei,Wang, Hai-Dong,Ye, Min,Yi, Yang,Zhang, Meng

    supporting information, (2022/01/06)

    Engineering the function of triterpene g...

    Synthetic Access Toward Cycloastragenol Glycosides

    Liu, Ting,Liao, Jin-Xi,Hu, Yang,Tu, Yuan-Hong,Sun, Jian-Song

    , p. 4170 - 4178 (2017/04/27)

    The first efficient synthetic approach t...

    Triterpene glycosides from Tragacantha stipulosa and their genins. Structure of cyclostipuloside E

    Kaipnazarov,Uteniyazov,Saatov

    , p. 40 - 44 (2007/10/03)

    The known compound trojanoside A(1) and ...

    83207-58-3 Process route

    3-O-(2,3,4-tri-O-benzoyl-β-D-xylopyranosyl)-6-O-(2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl)-16,25-di-O-acetylcycloastragenol

    3-O-(2,3,4-tri-O-benzoyl-β-D-xylopyranosyl)-6-O-(2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl)-16,25-di-O-acetylcycloastragenol

    astragaloside IV
    83207-58-3,84687-43-4

    astragaloside IV

    Conditions
    Conditions Yield
    With sodium methylate; In methanol; at 20 ℃; for 15h;
    76%
    astragaloside VI
    84687-45-6

    astragaloside VI

    astragaloside IV
    83207-58-3,84687-43-4

    astragaloside IV

    Conditions
    Conditions Yield
    hesperidinase; In water; acetone; at 35 ℃; for 36h;
    35 mg

    83207-58-3 Upstream products

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      isoastragaloside I

    • 84687-46-7
      84687-46-7

      (3β,6α,16β,20R,24S)-20,24-epoxy-16-hydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostane-6,25-diyl bis[β-D-glucopyranoside]

    83207-58-3 Downstream products

    • 84605-18-5
      84605-18-5

      cycloastragenol

    • 86764-12-7
      86764-12-7

      cyclosieversigenin 6-O-β-D-glucopyranoside

    • 86541-79-9
      86541-79-9

      astragenol

    • 86541-83-5
      86541-83-5

      cyclosieversigenin 3-O-β-D-xylopyranoside

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