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    84605-18-5

    • Product Name:Cycloastragenol
    • Molecular Formula:C30H50O5
    • Molecular Weight:490.724
    • Appearance:Colorless needle crystal
    Inquiry

    Product Details

    Appearance:Colorless needle crystal

    Purity:99%

    Factory Supply Hot Sale 84605-18-5 Cycloastragenol with Safe Transportation

    • Molecular Formula:C30H50O5
    • Molecular Weight:490.724
    • Appearance/Colour:Colorless needle crystal 
    • Vapor Pressure:8.17E-18mmHg at 25°C 
    • Refractive Index:1.582 
    • Boiling Point:617.2 °C at 760 mmHg 
    • PKA:14.57±0.29(Predicted) 
    • Flash Point:327.1 °C 
    • PSA:90.15000 
    • Density:1.2 g/cm3 
    • LogP:4.43660 

    Cycloastragenol(Cas 84605-18-5) Usage

    Description

    Cycloastragenol is a triterpenoid isolated from various legume species in the genus Astragalus that is purported to have telomerase activation activity. TA-65 is capable to increase average telomere length and to decrease the percentage of critically short telomeres and DNA damage in MEFs that harbor critically short telomeres. The effects on telomerase appear to be in common with other triterpenoid saponins (ie, ginsenosides RG1 and Rg3). These compounds at concentrations from 1 to 20 μM were reported to protect against IL-1β-, H2O2-, and tert-butylhydroperoxide-induced senescence in human chondrocytes, endothelial progenitor cells and fibroblasts, respectively.

    Uses

    Cycloastragenol is an aglycone derivative of astragaloside IV found in the root of Korean Astragalus membranaceus.

    Definition

    ChEBI: A sapogenin that is the aglycone derivative of astragaloside IV, a major saponin extracted from the root of Astragalus membranaceus.

    InChI:InChI=1/C30H50O5/c1-24(2)20(33)8-11-30-16-29(30)13-12-26(5)23(28(7)10-9-21(35-28)25(3,4)34)18(32)15-27(26,6)19(29)14-17(31)22(24)30/h17-23,31-34H,8-16H2,1-7H3/t17-,18-,19-,20-,21+,22?,23?,26+,27-,28-,29?,30?/m0/s1

    84605-18-5 Relevant articles

    Structure of cyclochivinoside C from Astragalus chivensis

    Naubeev,Uteniyazov

    , p. 560 - 562 (2007)

    The new cycloartane glycoside cyclochivi...

    Cycloascauloside a from Astragalus caucasicus leaves

    Alaniya,Chkadua,Gigoshvili,Kemertelidze

    , p. 445 - 448 (2006)

    The new cycloartane glycoside cycloascau...

    The use of two-phase acid hydrolysis method of preparing ring [...] (by machine translation)

    -

    Paragraph 0024-0066, (2019/07/08)

    The invention belongs to the field of ph...

    Compositions and methods for skin conditioning

    -

    Page/Page column 21, (2016/02/26)

    Methods and cosmetic compositions for co...

    Triterpene glycosides from astragalus. Structure of cyclolehmanoside C from A. lehmannianus

    Zhanibekov,Naubeev,Uteniyazov,Bobakulov, Kh. M.,Abdullaev

    , p. 475 - 477 (2013/09/02)

    The structure of a new cycloartane trite...

    Flavonoid and cycloartane glycosides from seeds of Koelreuteria paniculata

    Sutiashvili,Alaniya,Mshvildadze,Skhirtladze,Pichette,Lavoie

    , p. 395 - 397 (2013/07/26)

    -

    84605-18-5 Process route

    20S,24R-epoxycycloartan-3,6,16,25-tetraol-3-O-β-D-(2'-O-acetyl)xylopyranosyl-6-O-β-D-xylopyranoside
    84883-00-1

    20S,24R-epoxycycloartan-3,6,16,25-tetraol-3-O-β-D-(2'-O-acetyl)xylopyranosyl-6-O-β-D-xylopyranoside

    D-xylose
    58-86-6

    D-xylose

    20(S),24(R)-epoxy-9β,19-cyclolanostan-3β,6α,16β,25-tetrol
    84605-18-5

    20(S),24(R)-epoxy-9β,19-cyclolanostan-3β,6α,16β,25-tetrol

    Conditions
    Conditions Yield
    Acidic conditions;
     
    astragaloside IV
    83207-58-3,84687-43-4

    astragaloside IV

    cycloastragenol
    84605-18-5,90865-25-1,104112-00-7,78574-94-4

    cycloastragenol

    Conditions
    Conditions Yield
    With hydrogenchloride; In methanol; at 20 ℃; for 168h;
    64%
    With hydrogenchloride; In methanol; at 20 ℃; for 168h;
    64%
    With hydrogenchloride; In ethanol; benzene; for 24h; Heating;
    30 mg
    With sulfuric acid; In methanol; for 3h;
    30 mg
    Multi-step reaction with 2 steps
    1: 47 mg / H2SO4 / methanol / 4 h / Heating
    2: 17 mg / H2SO4 / methanol / 4 h / Heating
    With sulfuric acid; In methanol;
     
    Multi-step reaction with 2 steps
    1: 58 mg / H2SO4 / methanol / 4 h / Heating
    2: 11 mg / H2SO4 / methanol; H2O / 4 h / Heating
    With sulfuric acid; In methanol; water;
     
    With water; Acidic conditions;
     
    astragaloside IV; With sodium periodate; In methanol; water; at 20 ℃;
    With sodium tetrahydroborate; In methanol; at 20 ℃; for 24h;
    With sulfuric acid; In methanol; water; for 24h; pH=2;
    384 mg
    With hydrogenchloride; In methanol; chloroform; water; at 20 ℃; for 144h; Concentration;
     

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